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Article

High specificity but low sensitivity of mutation-specific antibodies against EGFR mutations in non-small-cell lung cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2014

Bondgaard Anna-Louise, Høgdall Estrid, Mellemgaard Anders, Skov Birgit G

Abstract excerpt

Determination of epidermal growth factor receptor (EGFR) mutations has a pivotal impact on treatment of non-small-cell lung cancer (NSCLC). A standardized test has not yet been approved. So far, Sanger DNA sequencing has been widely used. Its rather low sensitivity has led to the development of more sensitive methods including real-time PCR (RT-PCR). Immunohistochemistry with mutation-specific antibodies might be...

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Share to Antibodies, Monoclonal
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24762545
DOI: 10.1038/modpathol.2014.67

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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