Article
Suitable extracellular oxidoreduction potential inhibit rex regulation and effect central carbon and energy metabolism in Saccharopolyspora spinosa.
Microbial cell factories - 27 Aug 2014
Zhang Xiangmei, Xue Chaoyou, Zhao Fanglong, Li Dashuai, Yin Jing, Zhang Chuanbo, Caiyin Qinggele, Lu Wenyu
Abstract excerpt
BACKGROUND: Polyketides, such as spinosad, are mainly synthesized in the stationary phase of the fermentation. The synthesis of these compounds requires many primary metabolites, such as acetyl-CoA, propinyl-CoA, NADPH, and succinyl-CoA. Their synthesis is also significantly influenced by NADH/NAD+. Rex is the sensor of NADH/NAD+ redox state, whose structure is under the control of NADH/NAD+ ratio. The structure...
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