Proteome analysis of an attenuated Francisella tularensis dsbA mutant: identification of potential DsbA substrate proteins.

doi:10.1021/pr900570b

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Article

Proteome analysis of an attenuated Francisella tularensis dsbA mutant: identification of potential DsbA substrate proteins.

Journal of proteome research - 1 Nov 2009

Straskova Adela, Pavkova Ivona, Link Marek, Forslund Anna-Lena, Kuoppa Kerstin, Noppa Laila, Kroca Michal, Fucikova Alena, Klimentova Jana, Krocova Zuzana, Forsberg Ake, Stulik Jiri

Abstract excerpt

Francisella tularensis (F. tularensis) is highly infectious for humans via aerosol route and untreated infections with the highly virulent subsp. tularensis can be fatal. Our knowledge regarding key virulence determinants has increased recently but is still somewhat limited. Surface proteins are potential virulence factors and therapeutic targets, and in this study, we decided to target three genes encoding...

Topics

Animals
Bacterial Proteins
Cell Line
Chromatography, Liquid
Francisella tularensis
Humans
Isoelectric Focusing
Macrophages
Mass Spectrometry
Membrane Proteins
Mice
Mice, Inbred BALB C
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptides

Protein Disulfide-Isomerases

Proteome

Proteomics

Source

Open in PubMed

Identifiers

PMID: 19799467
DOI: 10.1021/pr900570b

Provenance

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