Article
Characterization of protein glycosylation in Francisella tularensis subsp. holarctica: identification of a novel glycosylated lipoprotein required for virulence.
Molecular & cellular proteomics : MCP - 1 Jul 2012
Balonova Lucie, Mann Benjamin F, Cerveny Lukas, Alley William R, Chovancova Eva, Forslund Anna-Lena, Salomonsson Emelie N, Forsberg Ake, Damborsky Jiri, Novotny Milos V, Hernychova Lenka, Stulik Jiri
Abstract excerpt
FTH_0069 is a previously uncharacterized strongly immunoreactive protein that has been proposed to be a novel virulence factor in Francisella tularensis. Here, the glycan structure modifying two C-terminal peptides of FTH_0069 was identified utilizing high resolution, high mass accuracy mass spectrometry, combined with in-source CID tandem MS experiments. The glycan observed at m/z 1156 was determined to be a...
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