Article
Voriconazole and atazanavir: a CYP2C19-dependent manageable drug-drug interaction.
Pharmacogenomics - 1 Jul 2014
Calcagno Andrea, Baietto Lorena, Pagani Nicole, Simiele Marco, Audagnotto Sabrina, D'Avolio Antonio, De Rosa Francesco Giuseppe, Di Perri Giovanni, Bonora Stefano
Abstract excerpt
AIM: To investigate the pharmacokinetics of voriconazole when administered to HIV-positive patients receiving treatment with atazanavir-containing therapies according to CYP2C19 genotype. MATERIALS & METHODS: We describe four HIV-positive patients with pulmonary aspergillosis treated with voriconazole and atazanavir-based regimens (with or without ritonavir). They were managed by assessing their CYP2C19 genotype...
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