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Article

Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia

30 May 2007

Abstract excerpt

The RAS proteins function as fundamental signaling switches that control normal cell growth and differentiation. Deregulated activation of RAS-dependent signaling pathways constitutes a potent mechanism of malignant cell transformation. Juvenile myelomonocytic leukemia (JMML) is a rapidly fatal myeloproliferative disorder of early childhood for which no effective treatment other than hematopoietic stem cell...

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Identifiers

PMID: 17584027
DOI: 10.2174/138945007780830773

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