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Article

Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer.

Oncogene - 1 Feb 2022

Alhayyani Sultan, McLeod Louise, West Alison C, Balic Jesse J, Hodges Christopher, Yu Liang, Smith Julian A, Prodanovic Zdenka, Bozinovski Steven, Kumar Beena, Ruwanpura Saleela M, Saad Mohamed I, Jenkins Brendan J

Abstract excerpt

The oncogenic potential of the latent transcription factor signal transducer and activator of transcription (STAT)3 in many human cancers, including lung cancer, has been largely attributed to its nuclear activity as a tyrosine-phosphorylated (pY705 site) transcription factor. By contrast, an alternate mitochondrial pool of serine phosphorylated (pS727 site) STAT3 has been shown to promote tumourigenesis by...

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PMID: 34857889
DOI: 10.1038/s41388-021-02134-4

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