Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression.

Human pathology - 1 Oct 2014

Oh Eun Ji, Yang Woo Ick, Cheong June-Won, Choi Sung-Eun, Yoon Sun Och

Abstract excerpt

Deregulation of histone H3 trimethylation at lysine 27 (H3K27me3) via aberration of the histone methyltransferase, enhancer of zeste homologue 2 (EZH2), is suggested to play a critical role in cancers including hematologic malignancies. In the present study, implications of H3K27me3 were investigated in diffuse large B-cell lymphoma (DLBCL) with respect to clinicopathological factors, especially in association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enhancer of Zeste Homolog 2 Protein
Share to Lymphoma, Large B-Cell, Diffuse

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Polycomb Repressive Complex 2

Share to Proportional Hazards Models

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to Tissue Array Analysis

Source

Identifiers

PMID: 25149548
DOI: 10.1016/j.humpath.2014.07.002

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression.PMID 25149548Read ↗

Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation.Semantic proximity Read ↗

EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features.Semantic proximity Read ↗

H3K27me3 Loss in Central Nervous System Tumors: Diagnostic, Prognostic, and Therapeutic ImplicationsSemantic proximity Read ↗

Immunohistochemical and genomic profiles of diffuse large B-cell lymphomas: Implications for targeted EZH2 inhibitor therapy?Semantic proximity Read ↗

The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's LymphomaSemantic proximity Read ↗

AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant LymphomaSemantic proximity Read ↗

Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes.Semantic proximity Read ↗

TP53 mutation is frequent in mantle cell lymphoma with EZH2 expression and have dismal outcome when both are present.Semantic proximity Read ↗

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination.Semantic proximity Read ↗

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).Semantic proximity Read ↗

Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 TrimethylationSemantic proximity Read ↗

Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.