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TP53 mutation is frequent in mantle cell lymphoma with EZH2 expression and have dismal outcome when both are present.

Human pathology - 1 Apr 2024

Kim Do Hwan, Siddiqui Saima, Jain Preetesh, Wang Michael, Thakral Beenu, Li Shaoying, Miranda Roberto, Vega Francisco, Medeiros L Jeffrey, Ok Chi Young

Abstract excerpt

Enhancer of zeste homolog 2 (EZH2) expression is found in about 40% of mantle cell lymphoma (MCL) patients, which is associated with aggressive histology, high Ki-67 proliferation rate, p53 mutant pattern and inferior overall survival (OS). We conducted 11-gene (ATM, BIRC3, CCND1, KMT2C, KMT2D, NOTCH1, NOTCH2, RB1, TP53, TRAF2 and UBR5) next generation sequencing panel to shed more light on MCL with EZH2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38460798
DOI: 10.1016/j.humpath.2024.03.002

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