Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features.

Human pathology - 1 Jun 2017

Liu Yang, Yu Kangjie, Li Mingyang, Zeng Kaixuan, Wei Jie, Li Xia, Liu Yixiong, Zhao Danhui, Fan Linni, Yu Zhou, Wang Yingmei, Li Zengshan, Zhang Wei, Bai Qingxian, Yan Qingguo, Guo Ying, Wang Zhe, Guo Shuangping

Abstract excerpt

Gastrointestinal diffuse large B-cell lymphoma (GI DLBCL) is the most common gastrointestinal lymphoma. Enhancer of zeste homolog 2 (EZH2) has been implicated in the pathogenesis of several cancers. However, EZH2 has not been studied in GI DLBCL. Thus, we investigated EZH2 expression and EZH2 Y641 mutation in 100 GI DLBCL specimens by immunohistochemistry and sequencing. In addition, trimethylated H3K27...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enhancer of Zeste Homolog 2 Protein
Share to Gastroenteritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

Share to Helicobacter Infections

Share to Lymphoma, Large B-Cell, Diffuse

Share to Neoplasm Grading

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 28438623
DOI: 10.1016/j.humpath.2017.04.011

Genes

BCL2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features.PMID 28438623Read ↗

Genomic Mutation Profile of Primary Gastrointestinal Diffuse Large B-Cell LymphomaSemantic proximity Read ↗

Heterogeneity in primary gastrointestinal DLBCL: from clinical management to molecular mechanisms and treatment strategies.Semantic proximity Read ↗

Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior.Semantic proximity Read ↗

Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation.Semantic proximity Read ↗

Differences in germinal centre and non-germinal center phenotype in gastric and intestinal diffuse large B-cell lymphomas.Semantic proximity Read ↗

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.Semantic proximity Read ↗

Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphomaSemantic proximity Read ↗

A20 (TNFAIP3) Alterations in Primary Intestinal Diffuse Large B-cell Lymphoma.Semantic proximity Read ↗

Colorectal diffuse large B-cell lymphoma: molecular subclassification and prognostic significance of immunoglobulin gene translocation.Semantic proximity Read ↗

[Analysis of the Gene Mutation Distribution and Its Relationship with Prognosis in Patients with Primary Gastrointestinal Diffuse Large B-Cell Lymphoma by Next Generation Sequencing].Semantic proximity Read ↗

Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma.Semantic proximity Read ↗

Immunohistochemical and genomic profiles of diffuse large B-cell lymphomas: Implications for targeted EZH2 inhibitor therapy?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.