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Article

Multivariate partial linear varying coefficients model for gene-environment interactions with multiple longitudinal traits.

Statistics in medicine - 30 Aug 2022

Wang Honglang, Zhang Jingyi, Klump Kelly L, Alexandra Burt Sybil, Cui Yuehua

Abstract excerpt

Correlated phenotypes often share common genetic determinants. Thus, a multi-trait analysis can potentially increase association power and help in understanding pleiotropic effect. When multiple traits are jointly measured over time, the correlation information between multivariate longitudinal responses can help to gain power in association analysis, and the longitudinal traits can provide insights on the...

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PMID: 35582816
DOI: 10.1002/sim.9440
PMCID: PMC9308731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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