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Article

Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN.

Cancer prevention research (Philadelphia, Pa.) - 1 Nov 2014

Piyathilake Chandrika J, Macaluso Maurizio, Chambers Michelle M, Badiga Suguna, Siddiqui Nuzhat R, Bell Walter C, Edberg Jeffrey C, Partridge Edward E, Alvarez Ronald D, Johanning Gary L

Abstract excerpt

We previously reported that a higher degree of methylation of CpG sites in the promoter (positions 31, 37, 43, 52, and 58) and enhancer site 7862 of human papillomavirus (HPV) 16 was associated with a lower likelihood of being diagnosed with HPV 16-associated CIN 2+. The purpose of this study was to replicate our previous findings and, in addition, to evaluate the influence of plasma concentrations of folate and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25145486
DOI: 10.1158/1940-6207.CAPR-14-0143
PMCID: PMC4711818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN.PMID 25145486Read ↗

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