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Article

Quantitative Measurement of L1 Human Papillomavirus Type 16 Methylation for the Prediction of Preinvasive and Invasive Cervical Disease.

The Journal of infectious diseases - 1 Mar 2017

Kottaridi Christine, Kyrgiou Maria, Pouliakis Abraham, Magkana Maria, Aga Evangelia, Spathis Aris, Mitra Anita, Makris George, Chrelias Charalampos, Mpakou Vassiliki, Paraskevaidis Evangelos, Panayiotides John G, Karakitsos Petros

Abstract excerpt

Background: Methylation of the human papillomavirus (HPV) DNA has been proposed as a novel biomarker. Here, we correlated the mean methylation level of 12 CpG sites within the L1 gene, to the histological grade of cervical precancer and cancer. We assessed whether HPV L1 gene methylation can predict the presence of high-grade disease at histology in women testing positive for HPV16 genotype. Methods:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28170039
DOI: 10.1093/infdis/jiw645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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