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Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia

31 Jul 2012

Abstract excerpt

We explored the association of human papillomavirus type 16 (HPV16) DNA methylation with age, viral load, viral persistence and risk of incident and prevalent high grade CIN (CIN2+) in serially collected specimens from the Guanacaste, Costa Rica cohort. 273 exfoliated cervical cell specimens (diagnostic and pre-diagnostic) were selected: (1) 92 with HPV16 DNA clearance (controls), (2) 72 with HPV16 DNA...

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Share to Epigenetics and DNA Methylation
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PMID: 22847263
DOI: 10.1002/ijc.27750

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