Article
A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia.
Cancer - 1 Mar 2011
Piyathilake Chandrika J, Macaluso Maurizio, Alvarez Ronald D, Chen Min, Badiga Suguna, Edberg Jeffrey C, Partridge Edward E, Johanning Gary L
Abstract excerpt
BACKGROUND: Although HPV 16 is the most common HPV genotype associated with cancerous lesions of the cervix, only a fraction of HPV 16 infected women are diagnosed with precancerous lesions of the cervix. Therefore, molecular changes in HPV 16, rather than infections per se, may serve as better screening or diagnostic biomarkers. The purpose of the study was to evaluate whether methylation status of specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.