Article
Genotype-specific methylation of HPV in cervical intraepithelial neoplasia.
Journal of gynecologic oncology - 1 Jul 2017
Hsu Yaw Wen, Huang Rui Lan, Su Po Hsuan, Chen Yu Chih, Wang Hui Chen, Liao Chi Chun, Lai Hung Cheng
Abstract excerpt
OBJECTIVE: Hypermethylation of human papillomavirus (HPV) and host genes has been reported in cervical cancer. However, the degree of methylation of different HPV types relative to the severity of the cervical lesions remains controversial. Studies of the degree of methylation associated with the host gene and the HPV genome to the severity of cervical lesions are rare. We examined the association of methylation...
Topics
- Alphapapillomavirus
- Biomarkers, Tumor
- CpG Islands
- DNA Methylation
- DNA, Viral
- Early Detection of Cancer
- Epigenesis, Genetic
- Female
- Genotype
- Human Papillomavirus DNA Tests
- Human papillomavirus 16
- Human papillomavirus 18
- Humans
- Paired Box Transcription Factors