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Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case–control study from the ASCUS-COL trial

21 Dec 2023

Abstract excerpt

PURPOSE: To our knowledge, there are very few studies evaluating if the levels of folate modify the risk of cervical intraepithelial neoplasia grade 2 and higher (CIN2+ and CIN3+) associated with the levels of HPV genome methylation, two cofactors related to single carbon metabolism and independently associated with cervical cancer in previous studies. We conducted a case-control study nested in a three-arm...

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PMID: 38129362
DOI: 10.1007/s00394-023-03289-4

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