Article
A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.
PloS one - 1 Jan 2014
Badiga Suguna, Johanning Gary L, Macaluso Maurizio, Azuero Andres, Chambers Michelle M, Siddiqui Nuzhat R, Piyathilake Chandrika J
Abstract excerpt
BACKGROUND: Studies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher grades of cervical intraepithelial neoplasia (CIN 2+). However, it is unknown whether exposure to higher folate as a result of the FA fortification program has altered the association between MTHFR C677T and risk of CIN, or the mechanisms...
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