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Article

Large germline copy number variations as predisposing factor in childhood neoplasms.

Future oncology (London, England) - 1 Jan 2014

Krepischi Ana Cristina Victorino, Capelli Leonardo Pires, Silva Amanda Gonçalves, de Araújo Érica Sara Souza, Pearson Peter Lees, Heck Benjamin, da Costa Cecília Maria Lima, de Camargo Beatriz, Rosenberg Carla

Abstract excerpt

AIMS: Constitutive genetic factors are believed to predispose to cancer in children. This study investigated the role of rare germline copy number variations (CNVs) in pediatric cancer predisposition. PATIENTS & METHODS: A total of 54 patients who developed cancer in infancy were screened by array-CGH for germline CNVs. RESULTS: In total, 12 rare CNVs were detected, including a Xq27.2 triplication, and two >1.8...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25145432
DOI: 10.2217/fon.14.41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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