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Article

Germline duplication of MYCN predisposes to childhood embryonal tumours.

EBioMedicine - 1 Feb 2026

Taylor Catherine A, May Philippa, Stone Thomas J, Ahmed Munaza, Chowdhury Tanzina, Tweddle Deborah A, Wilson Shaun, Hanscombe Ken, Hutchinson J Ciaran, Pickles Jessica C, Sebire Neil J, Jacques Thomas S

Abstract excerpt

BACKGROUND: Neuroblastoma and Wilms tumour (WT) are common childhood embryonal malignancies. Germline 2p24 duplication has been reported in several cases of neuroblastoma and WT, either as part of a larger 2p duplication or as a microduplication involving just 2p24.3. Although the larger duplications involve many genes, including ALK, the microduplications have been localised to a region including MYCN and DDX1....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to N-Myc Proto-Oncogene Protein

Share to Neoplasms, Germ Cell and Embryonal

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Source

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Identifiers

PMID: 41621405
DOI: 10.1016/j.ebiom.2026.106132
PMCID: PMC12878678

Genes

MYCN
DDX1
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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