Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.

Blood - 25 Sept 2014

Besancenot Rodolphe, Roos-Weil Damien, Tonetti Carole, Abdelouahab Hadjer, Lacout Catherine, Pasquier Florence, Willekens Christophe, Rameau Philippe, Lecluse Yann, Micol Jean-Baptiste, Constantinescu Stefan N, Vainchenker William, Solary Eric, Giraudier Stéphane

Abstract excerpt

Megakaryopoiesis is a 2-step differentiation process, regulated by thrombopoietin (TPO), on binding to its cognate receptor myeloproliferative leukemia (MPL). This receptor associates with intracytoplasmic tyrosine kinases, essentially janus kinase 2 (JAK2), which regulates MPL stability and cell-surface expression, and mediates TPO-induced signal transduction. We demonstrate that JAK2 and MPL mediate TPO-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iodide Peroxidase

Share to Iron-Binding Proteins

Share to Megakaryocytes

Share to Primary Myelofibrosis

Share to Receptors, Thrombopoietin

Share to Thrombocythemia, Essential

Source

Open in PubMed Open full text

Identifiers

PMID: 25143485
DOI: 10.1182/blood-2014-03-559815
PMCID: PMC4186539

Genes

JAK2
MPL
TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.PMID 25143485Read ↗

JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling.Semantic proximity Read ↗

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read ↗

miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient plateletsSemantic proximity Read ↗

The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasmSemantic proximity Read ↗

Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.Semantic proximity Read ↗

Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease.Semantic proximity Read ↗

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways.Semantic proximity Read ↗

Thrombopoietin signal transduction: studies from cell lines and primary cells.Semantic proximity Read ↗

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic ProliferationSemantic proximity Read ↗

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.Semantic proximity Read ↗

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet ProductionSemantic proximity Read ↗

Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.