Article
CpG-mediated modulation of MDSC contributes to the efficacy of Ad5-TRAIL therapy against renal cell carcinoma.
Cancer immunology, immunotherapy : CII - 1 Nov 2014
James Britnie R, Anderson Kristin G, Brincks Erik L, Kucaba Tamara A, Norian Lyse A, Masopust David, Griffith Thomas S
Abstract excerpt
Tumor progression occurs through the modulation of a number of physiological parameters, including the development of immunosuppressive mechanisms to prevent immune detection and response. Among these immune evasion mechanisms, the mobilization of myeloid-derived suppressor cells (MDSC) is a major contributor to the suppression of antitumor T-cell immunity. Patients with renal cell carcinoma (RCC) show increased...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.