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Article

HLA-B27 and Human β2-Microglobulin Affect the Gut Microbiota of Transgenic Rats

20 Aug 2014

Abstract excerpt

The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic arthritis, but its mechanism of risk enhancement is not completely understood. The gut microbiome has recently been shown to influence several HLA-linked diseases. However, the role of HLA-B27 in shaping the gut microbiome has not been previously investigated....

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PMID: 25140823
DOI: 10.1371/journal.pone.0105684

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