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Article

The role of the gut and intestinal dysbiosis in the pathogenesis of spondyloarthritis.

Joint bone spine - 1 Dec 2025

Mauro Daniele, Cai Benjamin, Ciancio Antonio, Forte Giulio, Gandolfo Saviana, Thomas Ranjeny, Bergot Anne-Sophie, Ciccia Francesco

Abstract excerpt

Spondyloarthritis (SpA) encompasses chronic inflammatory diseases affecting both axial and peripheral joints. Emerging evidence highlights a pivotal role for the gut-joint axis in SpA pathogenesis, where intestinal dysbiosis and barrier dysfunction facilitate microbial translocation and trigger systemic immune activation. Clinical observations of subclinical gut inflammation, alongside findings from HLA-B27...

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Identifiers

PMID: 40404007
DOI: 10.1016/j.jbspin.2025.105923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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