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Structural insights into substrate and coenzyme preference by SDR family protein Gox2253 from Gluconobater oxydans.

Proteins - 1 Nov 2014

Yin Bo, Cui Dongbing, Zhang Lujia, Jiang Shuiqin, Machida Satoru, Yuan Y Adam, Wei Dongzhi

Abstract excerpt

Gox2253 from Gluconobacter oxydans belongs to the short-chain dehydrogenases/reductases family, and catalyzes the reduction of heptanal, octanal, nonanal, and decanal with NADPH. To develop a robust working platform to engineer novel G. oxydans oxidoreductases with designed coenzyme preference, we adopted a structure based rational design strategy using computational predictions that considers the number of...

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PMID: 24825769
DOI: 10.1002/prot.24603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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