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Article

Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2014

Sharma Vineeta, Witkowski Andrzej, Witkowska H Ewa, Dykstra Andrew, Simonsen Jens B, Nelbach Lisa, Beckstead Jennifer A, Pullinger Clive R, Kane John P, Malloy Mary J, Watson Gordon, Forte Trudy M, Ryan Robert O

Abstract excerpt

OBJECTIVE: Apolipoprotein A-V (apoA-V) is a low-abundance plasma protein that modulates triacylglycerol homeostasis. Gene transfer studies were undertaken in apoa5 (-/-) mice to define the mechanism underlying the correlation between the single-nucleotide polymorphism c.553G>T in APOA5 and hypertriglyceridemia. APPROACH AND RESULTS: Adeno-associated virus (AAV) 2/8-mediated gene transfer of wild-type apoA-V...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25127531
DOI: 10.1161/ATVBAHA.114.304027
PMCID: PMC4178935

Genes

APOA5
SDS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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