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Interaction with AEG-1 and MDM2 is associated with glioma development and progression and correlates with poor prognosis

18 Dec 2018

Abstract excerpt

Glioma is the most common central nervous system tumor with poor prognosis. The AEG-1 (Astrocyte Elevated Gene 1) gene displays oncogenic characteristics, including proliferation, metastasis, chemoresistance, invasion, and evasion of apoptosis, and is strongly linked to the occurrence of glioma. Here, we elucidated the potential contribution of AEG-1 in human glioma pathogenesis. In glioma cells, AEG-1 could...

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PMID: 30560724
DOI: 10.1080/15384101.2018.1557489

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