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Astrocyte elevated gene‐1 and c‐Myc cooperate to promote hepatocarcinogenesis in mice

28 Jul 2014

Abstract excerpt

UNLABELLED: Astrocyte elevated gene-1 (AEG-1) and c-Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG-1 is transcriptionally regulated by c-Myc, and AEG-1 itself induces c-Myc by activating the Wnt/β-catenin-signaling pathway. We now document the cooperation of AEG-1 and c-Myc in promoting hepatocarcinogenesis by analyzing hepatocyte-specific transgenic mice expressing...

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PMID: 25065684
DOI: 10.1002/hep.27339

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