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Article

Epistasis effects of COMT and MTHFR on inter-individual differences in mental health: under the inverted U-shaped prefrontal dopamine model.

Biochemical and biophysical research communications - 5 Sept 2014

Htun Nay Chi, Miyaki Koichi, Zhao Chenxi, Muramatsu Masaaki, Sato Noriko

Abstract excerpt

Higher cognitive performance, maintenance of mental health and psychological well-being require adequate prefrontal cortex (PFC) function. "Inverted U-shaped" dopamine model indicates optimal PFC dopamine level is important to attain its function while high or low levels have adverse effects. Catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR) may be involved in this complex...

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Source

Identifiers

PMID: 25124664
DOI: 10.1016/j.bbrc.2014.08.023

Genes

MTHFR
COMT

Variants

rs4633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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