Article
Complotype affects the extent of down-regulation by Factor I of the C3b feedback cycle in vitro.
Clinical and experimental immunology - 1 Aug 2015
Lay E, Nutland S, Smith J E, Hiles I, Smith R A G, Seilly D J, Buchberger A, Schwaeble W, Lachmann P J
Abstract excerpt
Sera from a large panel of normal subjects were typed for three common polymorphisms, one in C3 (R102G) and two in Factor H (V62I and Y402H), that influence predisposition to age-related macular degeneration and to some forms of kidney disease. Three groups of sera were tested; those that were homozygous for the three risk alleles; those that were heterozygous for all three; and those homozygous for the low-risk...
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