Article
Characterization of genomic alterations and the significance of PI3K/mTOR pathway mutations and tumor mutational burden in non‑small cell lung cancer.
Oncology reports - 1 Jun 2020
Hu Jing, Shang Yanhong, Shi Xiaoliang, Zhang Shuirong, Shi Junping, Yao Ming, Wang Aodi, Shou Tao, Shi Weiwei, Wang Kai, Liu Angen, Pan Xiaojie, Wang Yongjie
Abstract excerpt
Lung cancer is the most prevalent cancer worldwide and non‑small cell lung cancer (NSCLC) is the most common subtype and accounts for 75% of all lung cancer cases. Although programmed death‑1/programmed death‑ligand‑1 (PD‑1/PD‑L1) blockade has shown good results in the clinic, numerous NSCLC patients still fail to respond to this therapy. In the current study, formalin‑fixed, paraffin‑embedded tumor and matched...
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