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Article

Next-generation sequencing reveals frequent consistent genomic alterations in small cell undifferentiated lung cancer.

Journal of clinical pathology - 1 Sept 2014

Ross J S, Wang K, Elkadi O R, Tarasen A, Foulke L, Sheehan C E, Otto G A, Palmer G, Yelensky R, Lipson D, Chmielecki J, Ali S M, Elvin J, Morosini D, Miller V A, Stephens P J

Abstract excerpt

AIMS: Small cell lung cancer (SCLC) carries a poor prognosis, and the systemic therapies currently used as treatments are only modestly effective, as demonstrated by a low 5-year survival at only ∼5%. In this retrospective collected from March 2013 to study, we performed comprehensive genomic profiling of 98 small cell undifferentiated lung cancer (SCLC) samples to identify potential targets of therapy not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24978188
DOI: 10.1136/jclinpath-2014-202447
PMCID: PMC4145440

Genes

BRCA2
CCND1
EGFR
EPHA3
FGFR1
KIT
KRAS
MCL1
PTEN
RICTOR
TSC1

Provenance

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