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Article

Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.

Atherosclerosis - 1 Jul 2016

Reschen Michael E, Lin Da, Chalisey Anil, Soilleux Elizabeth J, O'Callaghan Christopher A

Abstract excerpt

BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with phosphatase regulating activity. The mechanism whereby PHACTR1 influences CAD risk is unknown. We hypothesized that PHACTR1 would be expressed in human cell types relevant to CAD and...

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Source

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Identifiers

PMID: 27187934
DOI: 10.1016/j.atherosclerosis.2016.04.025
PMCID: PMC4917897

Genes

PHACTR1
CAD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.PMID 27187934Read ↗

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