Article
Pathological Diagnosis of Thyroid Nodules with Preoperatively Detected TERT Promoter Mutations in the Absence of BRAFV600E: A Bi-Center Series of 52 Cases.
Thyroid : official journal of the American Thyroid Association - 1 Oct 2025
Alzumaili Bayan A, Instrum Ryan, Alabkaa Anas, Sadow Peter M, Tuttle Michael R, Xu Bin, Morris Luc G T, Ghossein Ronald A
Abstract excerpt
Background: Mutations in the promoter region of TERT (TERTp) in thyroid nodules with indeterminate cytology are quoted to confer a high (∼80-95%) probability for thyroid carcinoma when detected on genomic classifier (GC) ThyroSeq. TERTp mutations may also occur in benign and low-risk thyroid neoplasms, and the risk of malignancy (ROM) in nodules harboring TERTp mutations without BRAFV600E is unknown. We analyzed...
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