Article
The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.
PloS one - 1 Jan 2014
Liu Xi, Yuan Hao, Peres Laurent, Chen Saijuan, Chen Zhu, de The Hugues, Zhou Jun, Zhu Jun
Abstract excerpt
PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL). It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells. Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-binding-defective PML/RARA mutants, were deficient in colony formation....
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