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Article

PML protein expression in hematopoietic and acute promyelocytic leukemia cells

15 Sept 1993

Abstract excerpt

Acute promyelocytic leukemia (APL) is thought to be caused by the t(15,17) translocation that fuses the PML gene to that of the retinoic acid receptor alpha (RAR alpha) and generates a PML/RAR alpha fusion protein. Yet, paradoxically, APL cells are exquisitely sensitive to retinoic acid (RA), as they terminally differentiate upon RA exposure. In this report, we have examined the expression of PML and PML/RAR...

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PMID: 8400236
DOI: 10.1182/blood.v82.6.1858.1858

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