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Article

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1.

Nature - 21 Aug 2014

Nguyen Phong Dang, Hollway Georgina Elizabeth, Sonntag Carmen, Miles Lee Barry, Hall Thomas Edward, Berger Silke, Fernandez Kristine Joy, Gurevich David Baruch, Cole Nicholas James, Alaei Sara, Ramialison Mirana, Sutherland Robert Lyndsay, Polo Jose Maria, Lieschke Graham John, Currie Peter David

Abstract excerpt

Haematopoietic stem cells (HSCs) are self-renewing stem cells capable of replenishing all blood lineages. In all vertebrate embryos that have been studied, definitive HSCs are generated initially within the dorsal aorta (DA) of the embryonic vasculature by a series of poorly understood inductive events. Previous studies have identified that signalling relayed from adjacent somites coordinates HSC induction, but...

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PMID: 25119043
DOI: 10.1038/nature13678

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