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Article

Pax6 is essential for the maintenance and multi-lineage differentiation of neural stem cells, and for neuronal incorporation into the adult olfactory bulb.

Stem cells and development - 1 Dec 2014

Curto Gloria G, Nieto-Estévez Vanesa, Hurtado-Chong Anahí, Valero Jorge, Gómez Carmela, Alonso José R, Weruaga Eduardo, Vicario-Abejón Carlos

Abstract excerpt

The paired type homeobox 6 (Pax6) transcription factor (TF) regulates multiple aspects of neural stem cell (NSC) and neuron development in the embryonic central nervous system. However, less is known about the role of Pax6 in the maintenance and differentiation of adult NSCs and in adult neurogenesis. Using the +/Sey(Dey) mouse, we have analyzed how Pax6 heterozygosis influences the self-renewal and proliferation...

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Identifiers

PMID: 25117830
DOI: 10.1089/scd.2014.0058
PMCID: PMC4235597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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