Article
Neuronal fate determinants of adult olfactory bulb neurogenesis.
Nature neuroscience - 1 Jul 2005
Hack Michael A, Saghatelyan Armen, de Chevigny Antoine, Pfeifer Alexander, Ashery-Padan Ruth, Lledo Pierre-Marie, Götz Magdalena
Abstract excerpt
Adult neurogenesis in mammals is restricted to two small regions, including the olfactory bulb, where GABAergic and dopaminergic interneurons are newly generated throughout the entire lifespan. However, the mechanisms directing them towards a specific neuronal phenotype are not yet understood. Here, we demonstrate the dual role of the transcription factor Pax6 in generating neuronal progenitors and also in...
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