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Article

Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome.

Neurobiology of disease - 1 Feb 2009

Tervonen Topi A, Louhivuori Verna, Sun Xiaohong, Hokkanen Marie-Estelle, Kratochwil Claudius F, Zebryk Pawel, Castrén Eero, Castrén Maija L

Abstract excerpt

The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors. Here, we show abnormalities in neurogenesis in the mouse and human embryonic FMRP-deficient brain as well as after in utero transfection of I304N mutated FMRP, which acts in a...

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Identifiers

PMID: 19056494
DOI: 10.1016/j.nbd.2008.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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