Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Dec 2015

Umićević Mirkov Maša, Janss Luc, Vermeulen Sita H, van de Laar Mart A F J, van Riel Piet L C M, Guchelaar Henk-Jan, Brunner Han G, Albers Cornelis A, Coenen Marieke J H

Abstract excerpt

OBJECTIVES: Pharmacogenetic studies of tumour necrosis factor inhibitors (TNFi) response in patients with rheumatoid arthritis (RA) have largely relied on the changes in complex disease scores, such as disease activity score 28 (DAS28), as a measure of treatment response. It is expected that genetic architecture of such complex score is heterogeneous and not very suitable for pharmacogenetic studies. We aimed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Antirheumatic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Genome-Wide Association Study

Share to Polymorphism, Genetic

Share to Severity of Illness Index

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 25114059
DOI: 10.1136/annrheumdis-2014-205541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis.PMID 25114059Read ↗

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study.Semantic proximity Read ↗

Comprehensive analysis of treatment response phenotypes in rheumatoid arthritis for pharmacogenetic studies.Semantic proximity Read ↗

Pharmacogenetics of TNF inhibitor response in rheumatoid arthritis utilizing the two-component disease activity score.Semantic proximity Read ↗

Genetic and Genomic Markers of Anti-TNF Treatment Response in Rheumatoid ArthritisSemantic proximity Read ↗

Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci.Semantic proximity Read ↗

A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid ArthritisSemantic proximity Read ↗

Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis.Semantic proximity Read ↗

Pharmacogenomics of Anti-TNF Treatment Response Marks a New Era of Tailored Rheumatoid Arthritis Therapy.Semantic proximity Read ↗

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.Semantic proximity Read ↗

Do genetics contribute to TNF inhibitor response prediction in Psoriatic Arthritis?Semantic proximity Read ↗

Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study.Semantic proximity Read ↗

Genetic variants in the TNF pathway impact TNFi response in a mixed population with rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.