Article
Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2014
Cooper J Mark, Wiklander P B Oscar, Nordin Joel Z, Al-Shawi Raya, Wood Matthew J, Vithlani Mansi, Schapira Anthony H V, Simons J Paul, El-Andaloussi Samir, Alvarez-Erviti Lydia
Abstract excerpt
Alpha-synuclein (α-Syn) aggregates are the main component of Lewy bodies, which are the characteristic pathological feature in Parkinson's disease (PD) brain. Evidence that α-Syn aggregation can be propagated between neurones has led to the suggestion that this mechanism is responsible for the stepwise progression of PD pathology. Decreasing α-Syn expression is predicted to attenuate this process and is thus an...
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