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Article

p16INK4a/Ki‐67 co‐expression specifically identifies transformed cells in the head and neck region

19 Aug 2014

Abstract excerpt

p16(INK4a) immunohistochemical overexpression is an overall reliable surrogate marker of human papillomavirus (HPV)-associated head and neck squamous cell carcinomas (HNSCC). However, cases of ambiguous p16(INK4a) overexpression are regularly detected in the head and neck: p16(INK4a) expression can be observed in non-malignant tissue, such as tonsillar crypt epithelium and a proportion of branchial cleft cysts....

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PMID: 25104331
DOI: 10.1002/ijc.29130

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