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p16 <sup>INK4A</sup> Immunohistochemical Overexpression in Premalignant and Malignant Oral Lesions Infected with Human Papillomavirus

1 Oct 2003

Abstract excerpt

Human papillomavirus (HPV) is believed to promote the oncogenic process, and the correlation between viral oncoproteins and dysfunction of p16(INK4A) tumor suppressor protein in oral lesions is controversial. To test the hypothesis that anogenital HPV types participate in disruption of the regulation of p16(INK4A) suppressor protein in oral lesions, we analyzed 46 oral biopsy specimens for the presence of HPV...

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PMID: 14500697
DOI: 10.1177/002215540305101006

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