Article
CD4(+)CD25 (+) regulatory T cells are not required for mesenchymal stem cell function in fully MHC-mismatched mouse cardiac transplantation.
Cell and tissue research - 1 Nov 2014
Jiang Xiaofeng, Liu Chen, Hao Jianpeng, Guo Dawei, Guo Jinshuai, Yao Junchao, Jiang Kun, Cui Zheming, Zhu Lei, Sun Wenyu, Lin Lin, Liang Jian
Abstract excerpt
Although the immunomodulative properties of mesenchymal stem cells (MSCs) open up attractive possibilities in solid-organ transplantation, information concerning the optimal dose, route, timing of administration, major histocompatibility complex (MHC)-restriction and relevant mechanisms is currently lacking. Therefore, better characterization of MSC immunoregulatory activity and elucidation of its mechanisms are...
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