Article
The synergistic immunoregulatory effects of culture-expanded mesenchymal stromal cells and CD4(+)25(+)Foxp3+ regulatory T cells on skin allograft rejection.
PloS one - 1 Jan 2013
Lee Jung Ho, Jeon Eun-Joo, Kim Nayoun, Nam Young-Sun, Im Keon-Il, Lim Jung-Yeon, Kim Eun-Jung, Cho Mi-La, Han Ki Taik, Cho Seok-Goo
Abstract excerpt
Mesenchymal stromal cells (MSCs) are seen as an ideal source of cells to induce graft acceptance; however, some reports have shown that MSCs can be immunogenic rather than immunosuppressive. We speculate that the immunomodulatory effects of regulatory T cells (Tregs) can aid the maintenance of im...
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