Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Bülow Hannes E, Berry Katherine L, Topper Liat H, Peles Elior, Hobert Oliver

Abstract excerpt

Kallmann syndrome is a neurological disorder characterized by various behavioral and neuroanatomical defects. The X-linked form of this disease is caused by mutations in the KAL-1 gene, which codes for a secreted molecule that is expressed in restricted regions of the brain. Its molecular mechanism of action has thus far remained largely elusive. We show here that expression of the Caenorhabditis elegans homolog...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Axons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion Molecules

Share to Cosmids

Share to Extracellular Matrix Proteins

Share to Heparan Sulfate Proteoglycans

Share to Immunoblotting

Share to Kallmann Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 11983919
DOI: 10.1073/pnas.092128099
PMCID: PMC122951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.PMID 11983919Read ↗

Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations.Semantic proximity Read ↗

The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching.Semantic proximity Read ↗

Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.Semantic proximity Read ↗

Kallmann's syndrome: molecular pathogenesis.Semantic proximity Read ↗

Syndecan regulates cell migration and axon guidance in C. elegans.Semantic proximity Read ↗

Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.Semantic proximity Read ↗

Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development.Semantic proximity Read ↗

Extracellular sugar modifications provide instructive and cell-specific information for axon-guidance choices.Semantic proximity Read ↗

C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.Semantic proximity Read ↗

The <i>C. elegans</i> ephrin EFN-4 functions non-cell autonomously with heparan sulfate proteoglycans to promote axon outgrowth and branchingSemantic proximity Read ↗

Regulation of axonal midline guidance by prolyl 4-hydroxylation in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.