Article
Extracellular sugar modifications provide instructive and cell-specific information for axon-guidance choices.
Current biology : CB - 23 Dec 2008
Bülow Hannes E, Tjoe Nartono, Townley Robert A, Didiano Dominic, van Kuppevelt Toin H, Hobert Oliver
Abstract excerpt
Heparan sulfates (HSs) are extraordinarily complex extracellular sugar molecules that are critical components of multiple signaling systems controlling neuronal development. The molecular complexity of HSs arises through a series of specific modifications, including sulfations of sugar residues and epimerizations of their glucuronic acid moieties. The modifications are introduced nonuniformly along...
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