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Article

Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells.

Hepatology (Baltimore, Md.) - 1 Dec 2014

Dubois-Pot-Schneider Hélène, Fekir Karim, Coulouarn Cédric, Glaise Denise, Aninat Caroline, Jarnouen Kathleen, Le Guével Rémy, Kubo Takashi, Ishida Seiichi, Morel Fabrice, Corlu Anne

Abstract excerpt

UNLABELLED: Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and resistance to therapies. Recent studies have reported that HCC may be derived not only from adult hepatocytes and hepatoblasts but also hepatic stem/progenitors. In this context, HepaRG cells may represent a suitable cellular model to study stem/progenitor cancer cells and the retrodifferentiation of tumor-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25098666
DOI: 10.1002/hep.27353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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