Article
Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue.
Metallomics : integrated biometal science - 1 Oct 2014
Ciccotosto Giuseppe D, James Simon A, Altissimo Matteo, Paterson David, Vogt Stefan, Lai Barry, de Jonge Martin D, Howard Daryl L, Bush Ashley I, Cappai Roberto
Abstract excerpt
The amyloid precursor protein (APP) gene family includes APP and the amyloid precursor-like proteins, APLP1 and APLP2. These proteins contain metal binding sites for copper, zinc and iron and are known to have physiological roles in modulating the metal homeostasis in brain cells. Here we report the application of X-ray fluorescence microscopy (XFM) to investigate the subcellular distribution patterns of the...
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